A grade III or grade IV glioma arising from the central nervous system. This category includes glioblastoma, anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligodendroglioma, and anaplastic oligoastrocytoma. The disease is malignant glioma (MONDO_0100342). Also known as: glial cell tumor, glial cell tumour, glioma, malignant, high grade glioma, high-grade glioma, malignant glial neoplasm, malignant glial tumor, malignant glial tumour.