Any acute myeloid leukemia that has the chromosomal anomaly Monosomy 5. (A cytogenetic aneuploidy abnormality that refers to the presence of one chromosome 5 only. It is associated with the development of refractory anemia with excess blasts, refractory anemia with multilineage dysplasia, and refractory anemia with multilineage dysplasia and ringed sideroblasts.). The disease is Monarch Disease Ontology term MONDO_0100388 (acute myeloid leukemia, Monosomy 5). Also known as: AML, Monosomy 5.