Any acute myeloid leukemia that has the chromosomal anomaly t(16;21)(q24;q22). (A cytogenetic abnormality that refers to the translocation of the long arm (q24) of chromosome 16 and the long arm (q22) of chromosome 22. It is associated with RUNX1/CBFA2T3 fusions, myelodysplastic syndromes and acute myeloid leukemia.). The disease is acute myeloid leukemia, t(16;21)(q24;q22) (Monarch Disease Ontology id MONDO_0100408). Also known as: AML, t(16;21)(q24;q22).