Any acute myeloid leukemia that has the chromosomal anomaly RUNX1 gene mutation. (A change in the nucleotide sequence of the RUNX1 gene.). The disease is acute myeloid leukemia, RUNX1 gene mutation (Monarch Disease Ontology entry MONDO_0100422). Also known as: AML, AML1 Gene Mutation, AML, AML1 Mutation, AML, AMLCR1 Gene Mutation, AML, Acute Myeloid Leukaemia 1 Gene Mutation, AML, Acute Myeloid Leukemia 1 Gene Mutation, AML, CBFA2 Gene Mutation, AML, CBFalpha2 Mutation, AML, RUNX1 gene mutation.