A rare autosomal dominant disease characterized by a complex phenotype including progressive dementia, apraxia, apathy, impaired balance, parkinsonism, spasticity and epilepsy. The disease is MONDO_0800027 (leukoencephalopathy, diffuse hereditary, with spheroids 1). Also known as: ALSP, Adult-Onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia, CSF1R-related ALSP, CSF1R-related adult-onset leukoencephalopathy with axonal spheroids and pigmented glia, FPSG, GPSC, POLD, adult-onset leukoencephalopathy with axonal spheroids and pigmented glia.