An autosomal recessive cancer predisposition syndrome characterized by the onset of various types of tumors or malignancies in young adulthood. The most common clinical manifestations include acute myeloid leukemia (AML), myelodysplastic syndrome, colorectal adenomatous polyposis and carcinoma, and uveal melanoma. The disease is MONDO_0859267 (tumor predisposition syndrome 2). Also known as: MANS, MBD4-associated neoplasia syndrome, MBD4-related recessive tumor predisposition syndrome, TPDS2.