A neuroocular syndrome caused by a mutation in PRR12 gene. It encompasses a broad spectrum of overlapping anomalies, with developmental delay or impaired intellectual development as a consistent finding. Eye abnormalities show marked variability in the type and severity of defects, and include anophthalmia, microphthalmia, and coloboma. Other common systemic features include congenital heart and kidney defects, hypotonia, failure to thrive, and microcephaly. The disease is Monarch Disease Ontology term MONDO_0971007 (neuroocular syndrome 1). Also known as: multiple congenital anomalies-neurodevelopmental delay-ocular abnormalities syndrome.