MONDO_8000010 (antiphospholipid syndrome) is a disorder caused by the presence of autoantibodies directed against phospholipids, causing a hypercoaguable state, which may result in blood clots, stroke, heart attack, and in women, significant pregnancy-related complications, including miscarriage and still birth. The syndrome is often associated with other autoimmune disorders, most commonly lupus erythematosus, and infections, including syphilis and Lyme disease. Also known as: Hughes syndrome, antiphospholipid antibody syndrome, familial lupus anticoagulant.