Orphanet_101 (Dentatorubral pallidoluysian atrophy) (DRPLA) is a rare subtype of type I autosomal dominant cerebellar ataxia (ADCA type I; see this term). It is characterized by involuntary movements, ataxia, epilepsy, mental disorders, cognitive decline and prominent anticipation. Also known as: DRPLA, Dentatorubropallidoluysian atrophy, Naito-Oyanagi disease.