The symptoms and/or signs of branchio-oto-renal syndrome are consistent with underdeveloped (hypoplastic) or absent kidneys with resultant renal insufficiency or renal failure.Ear anomalies include extra openings in front of the ears, extra pieces of skin in front of the ears (preauricular tags), or further malformation or absence of the outer ear (pinna). Malformation or absence of the middle ear is also possible, individuals can have mild to profound hearing loss. People with BOR may also have cysts or fistulae along the sides of their neck. The disease is Orphanet rare-disease nomenclature term Orphanet_107 (BOR syndrome). Also known as: BOR, Branchio-otorenal dysplasia, Branchiootorenal syndrome, Melnick-Fraser syndrome, branchio-oto-renal syndrome, branchiootorenal dysplasia.