Cerebellar ataxia - hypogonadism, also known as Gordon-Holmes syndrome, is a very rare autosomal recessive neurodegenerative disorder characterized by the combination of progressive cerebellar ataxia with onset from early childhood to the fourth decade, and hypogonadotropic hypogonadism (delayed puberty and lack of secondary sex characteristics). Cerebellar ataxia - hypogonadism belongs to a clinical continuum of neurodegenerative disorders along with clinically overlapping disorders such as Ataxia - hypogonadism - choroidal dystrophy (see this term). The disease is Orphanet rare-disease nomenclature entry Orphanet_1173 (Cerebellar ataxia - hypogonadism). Also known as: Gordon-Holmes syndrome, Luteinizing hormone-releasing hormone deficiency with ataxia.