Congenital atransferrinemia is a very rare hematologic disease caused by a transferrin (TF) deficiency and characterized by microcytic, hypochromic anemia (manifesting with pallor, fatigue and growth retardation) and iron overload, and that can be fatal if left untreated. The disease is Orphanet_1195 (Congenital atransferrinemia). Also known as: Congenital hypotransferrinemia.