Dermato-cardio-skeletal syndrome, Borrone type (Orphanet_1266) can be described as follows. Dermatocardioskeletal syndrome, Borrone type, is a malformation syndrome characterized by a coarse facies with full lips, severe acne (acne conglobata), mitral valve prolapse, brachydactyly and vertebral abnormalities. The onset of debilitating dermato-cardio-skeletal manifestations has been reported at around puberty. With age and the progression of this disorder, osteolysis, flexion contractures of large joints, gingival hypertrophy and thick skin have been reported.