CADASIL (Orphanet_136) (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is a hereditary cerebrovascular disorder characterized by mid-adult onset of recurrent subcortical ischemic stroke and cognitive impairment progressing to dementia in addition to migraines with aura and mood disturbances seen in about a third of patients. Also known as: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, Hereditary multi-infarct dementia.