Adult-onset dystonia-parkinsonism is a rare neurodegenerative disease usually presenting before the age of 30 and which is characterized by dystonia, L-dopa-responsive parkinsonism, pyramidal signs and rapid cognitive decline. The disease is Orphanet_199351 (Adult-onset dystonia-parkinsonism). Also known as: Dystonia-parkinsonism, Paisan-Ruiz type, PARK14, PLA2G6-related dystonia-parkinsonism.