Acro-cardio-facial syndrome (ACFS) is a rare genetic disorder characterized by split-hand/split-foot malformation (SHFM), facial anomalies, cleft lip/palate, congenital heart defect (CHD), genital anomalies, and intellectual deficit. The disease is Orphanet_2008 (Acro-cardio-facial syndrome). Also known as: ACFS, CCGE syndrome, Cleft palate - cardiac defect - genital anomalies - ectrodactyly.