Orphanet rare-disease nomenclature identifier Orphanet_2211 (Hypertelorism - hypospadias - polysyndactyly syndrome) can be described as follows. Hypertelorism-hypospadias-polysyndactyly syndrome is a very rare syndrome associating an acro-fronto-facio-nasal dysostosis with genitourinary anomalies. Also known as: Acro-fronto-facio-nasal dysostosis type 2, Acro-fronto-facio-nasal syndrome type 2, Naguib-Richieri-Costa syndrome.