Macrocephaly - spastic paraplegia - dysmorphism (Orphanet_2429, an Orphanet rare-disease nomenclature id) is a rare syndrome of multiple congenital anomalies characterized by macrocephaly (of post-natal onset) with large anterior fontanelle, progressive complex spastic paraplegia, coarse facial features (broad and high forehead, deeply set eyes, short philtrum with thin upper lip, large mouth and prominent incisors), seizures, and intellectual deficit of varying severity. Inheritance appears to be autosomal recessive. Also known as: Fryns macrocephaly.