46,XX gonadal dysgenesis (46,XX GD) is a primary ovarian defect leading to premature ovarian failure (POF; see this term) in otherwise normal 46,XX females as a result of failure of the gonads to develop or due to resistance to gonadotrophin stimulation. The disease is 46,XX gonadal dysgenesis (Orphanet_243). Also known as: 46,XX complete gonadal dysgenesis, 46,XX ovarian dysgenesis, 46,XX pure gonadal dysgenesis, FSH-RO, Follicular stimulating hormone-resistant ovaries, Hypergonadotropic ovarian dysgenesis, XX female gonadal dysgenesis, XX-GD.