Orphanet_245 (Nager syndrome), also called Nager acrofacial dysostosis (NAFD) is a congenital malformation syndrome characterized by mandibulofacial dystosis (malar hypoplasia, micrognathia, external ear malformations) and variable preaxial limb defects. Also known as: Mandibulofacial dysostosis with preaxial limb anomalies, NAFD, Nager acrofacial dysostosis, Preaxial acrodysostosis.