Neurofibromatosis type 6 (NF6), also referred as café-au-lait spots syndrome, is a cutaneous disorder characterized by the presence of several café-au-lait (CAL) macules without any other manifestations of neurofibromatosis or any other systemic disorder. The disease is Neurofibromatosis type 6 (Orphanet_2678). Also known as: Familial café-au-lait spots, Multiple café-au-lait spots, Multiple café-au-lait syndrome, NF6.