Arthrogryposis-Renal dysfunction-Cholestasis (ARC) syndrome is a multisystem disorder, characterized by neurogenic arthrogryposis multiplex congenita, renal tubular dysfunction and neonatal cholestasis with low serum gamma-glutamyl transferase activity. The disease is Arthrogryposis - renal dysfunction - cholestasis (Orphanet rare-disease nomenclature id Orphanet_2697). Also known as: ARC syndrome.