Oral-facial-digital syndrome, type 8 is characterized by tongue lobulation, hypoplasia of the epiglottis, median cleft upper lip, broad or bifid nasal tip, hypertelorism or telecanthus, bilateral preaxial and postaxial polydactyly, abnormal tibiae and/or radii, duplication of the halluces, short stature, and mild intellectual deficit. The disease is Orphanet rare-disease nomenclature entry Orphanet_2755 (Orofaciodigital syndrome type 8). Also known as: OFD8, Oral-facial-digital syndrome type 8, Oral-facial-digital syndrome, Edwards type, Orofaciodigital syndrome, Edwards type.