Autoimmune lymphoproliferative syndrome (ALPS) with recurrent viral infections is a rare genetic disorder characterized by lymphadenopathy and/or splenomegaly and recurrent infections due to herpes viruses. The disease is Autoimmune lymphoproliferative syndrome with recurrent viral infections (Orphanet_275517, an Orphanet rare-disease nomenclature term). Also known as: ALPS with recurrent viral infections, CEDS, Caspase 8 deficiency syndrome, Caspase eight deficiency state.