Xeroderma pigmentosum complementation group E (XPE) is an extremely rare subtype of xeroderma pigmentosum (XP; see this term), a rare photodermatosis predisposing to skin cancers. The disease is Orphanet rare-disease nomenclature identifier Orphanet_276261 (Xeroderma pigmentosum complementation group E). Also known as: XPE.