Orphanet rare-disease nomenclature term Orphanet_3421 (Cerebroretinal vasculopathy) (CRV) is a phenotypic variant of a group of inherited small vessel disorders known as retinal vasculopathy and cerebral leukodystrophy (RVCL; see this term), characterized by strokes, vision loss, migraines, pseudotumours, dementia and occasionally renal disease. Also known as: CRV, Grand-Kaine-Fulling syndrome.