Hereditary persistence of fetal hemoglobin - beta-thalassemia (Orphanet_46532) is hereditary persistence of fetal hemoglobin (HPFH) associated with beta-thalassemia (see this term) is characterized by high hemoglobin (Hb) F levels and an increased number of fetal-Hb-containing-cells. Also known as: HPFH - beta-thalassemia.