Larsen syndrome (LS) is a rare skeletal dysplasia characterized by congenital dislocation of large joints, foot deformities, cervical spine dysplasia, scoliosis, spatula-shaped distal phalanges and distinctive craniofacial abnormalities, including cleft palate. The disease is Orphanet rare-disease nomenclature term Orphanet_503 (Autosomal dominant Larsen syndrome).