Papillon-Lefèvre syndrome (PLS) is a rare ectodermal dysplasia characterized by palmoplantar keratoderma associated with early-onset periodontitis. The disease is Orphanet_678 (Papillon-Lefèvre syndrome). Also known as: Keratosis palmoplantar - periodontopathy, PLS, Papillon Lefevre syndrome, Papillon-Lefevre Disease, Papillon-Lefvre syndrome (disorder).