Localized epidermolysis bullosa simplex, formerly known as EBS, Weber-Cockayne, is a basal subtype of epidermolysis bullosa simplex (EBS, see this term). The disease is characterized by blisters occurring mainly on the palms and soles, exacerbated by warm weather. The disease is Localized epidermolysis bullosa simplex (Orphanet_79400). Also known as: EBS-loc, Epidermolysis bullosa simplex of palms and soles, Epidermolysis bullosa simplex, Weber-Cockayne type.