Syndromic diarrhea (SD), or tricho-hepato-enteric syndrome (THE), is a severe congenital enteropathy manifesting as intractable diarrhea in the first month of life with failure to thrive and associated with facial dysmorphism, hair abnormalities, and, in some cases, immune disorders and intrauterine growth restriction. The disease is Orphanet_84064 (Syndromic diarrhea). Also known as: Phenotypic diarrhea, SD/THE, Syndromatic diarrhea, Syndromic diarrhea/Tricho-hepato-enteric syndrome, Tricho-hepato-enteric syndrome.