Hereditary cerebral hemorrhage with amyloidosis (Orphanet_85458, an Orphanet rare-disease nomenclature entry) (HCHWA) describes a group of rare familial central nervous system disorders characterized by amyloid deposition in the cerebral blood vessels leading to hemorrhagic and non-hemorrhagic strokes, focal neurological deficits, and progressive cognitive decline eventually leading to dementia. Also known as: HCHWA.