Triple A syndrome is a very rare multisystem disease characterized by adrenal insufficiency with isolated glucocorticoid deficiency, achalasia, alacrima, autonomic dysfunction and neurodegeneration. The disease is Orphanet rare-disease nomenclature term Orphanet_869 (Triple A syndrome). Also known as: 2A syndrome, 3A syndrome, 4A syndrome, AAA syndrome, Achalasia - addisonianism - alacrima syndrome, Adrenal insufficiency - achalasia - alacrima, Allgrove syndrome, Double A syndrome.