Orphanet rare-disease nomenclature term Orphanet_93262 (Crouzon syndrome - acanthosis nigricans) can be described as follows. Crouzon syndrome with acanthosis nigricans (CAN) is a very rare, clinically heterogeneous form of faciocraniostenosis with Crouzon-like features (see this term) with premature synostosis of cranial sutures associated with acanthosis nigricans. Also known as: Crouzon-dermoskeletal syndrome.