Combined vitamin K-dependent clotting factors deficiency (VKCFD) is a congenital bleeding disorder resulting from variably decreased levels of coagulation factors II, VII, IX and X, as well as natural anticoagulants protein C, protein S and protein Z. The disease is Orphanet_98434 (Hereditary combined deficiency of vitamin K-dependent clotting factors). Also known as: Hereditary combined deficiency of factors II, VII, IX and X.