Orphanet_99015 (Spastic paraplegia type 2) (SPG2) is an X-linked leukodystrophy characterized primarily by spastic gait and autonomic dysfunction. When additional central nervous system (CNS) signs, such as intellectual deficit, ataxia, or extrapyramidal signs, are present, the syndrome is referred to as complicated SPG. Also known as: SPG2, Spastic gait type 2, Spastic paraparesis type 2, X-linked spastic paraplegia type 2.