Autosomal dominant Charcot-Marie-Tooth disease type 2I (Orphanet_99942) (CMT2I) is a form of axonal Charcot-Marie-Tooth disease, a peripheral sensorimotor neuropathy, characterized by a late onset with severe sensory loss (paresthesia and hypoesthesia) associated with distal weakness, mainly of the legs, and absent or reduced deep tendon reflexes. Also known as: CMT2I.