Autosomal dominant Charcot-Marie-Tooth disease type 2A1 (CMT2A1) is a form of axonal Charcot-Marie-Tooth disease, a peripheral sensorimotor neuropathy. CMT2A presents with a more prominent muscle weakness in lower than upper limbs and frequent postural tremor. The disease is Orphanet_99946 (Autosomal dominant Charcot-Marie-Tooth disease type 2A1). Also known as: CMT2A1.