The function of ARF5 (ARF GTPase 5, ENSG00000004059) is as follows. GTP-binding protein involved in protein trafficking. Contributes to vesicle budding and uncoating at the Golgi apparatus. Regulates mTORC1 activity at the plasma membrane by promoting its recruitment to membrane ruffles, facilitating activation via the PI3K/Akt signaling pathway (PubMed:36735494). Acts as an early responder to lysosomal damage and participates in lysosomal quality control pathways (PubMed:41293316). {ECO:0000269|PubMed:36735494, ECO:0000269|PubMed:41293316}. (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. .