The function of Ensembl gene identifier ENSG00000007384 (RHBDF1, rhomboid 5 homolog 1) is as follows. Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation (PubMed:15965977, PubMed:18524845, PubMed:18832597, PubMed:21439629). Does not exhibit any protease activity on its own (PubMed:21439629). Regulator of proteosomal assembly by promoting formation of the proteosome assembly chaperone PSMG1-PSMG2 heterodimer, positively regulating proteosome activity (PubMed:26109405). {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18524845, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629, ECO:0000269|PubMed:26109405}.