The function of Ensembl gene identifier ENSG00000011422 (PLAUR, plasminogen activator, urokinase receptor) is as follows. GPI-anchored receptor that recruits and activates the urokinase-type plasminogen activator (uPA) at the cell surface. Activated uPA converts plasminogen into plasmin, initiating extracellular matrix degradation and remodeling (PubMed:1689240, PubMed:15677461). Also binds the extracellular matrix protein vitronectin, promoting cell-matrix adhesion and indirectly integrin signaling (PubMed:17548516, PubMed:25168639, PubMed:28849762). This dual interaction coordinates dynamic changes in cell migration, proliferation, and tissue remodeling (PubMed:28849762). {ECO:0000269|PubMed:15677461, ECO:0000269|PubMed:1689240, ECO:0000269|PubMed:17548516, ECO:0000269|PubMed:25168639, ECO:0000269|PubMed:28849762}.