The function of RNF10 (ring finger protein 10, Ensembl gene identifier ENSG00000022840) is as follows. E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling (PubMed:34348161, PubMed:34469731, PubMed:39609413, PubMed:39947182, PubMed:39947183, PubMed:40022732). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC) or elongation (PubMed:34348161, PubMed:34469731, PubMed:39609413, PubMed:39947182, PubMed:39947183, PubMed:40022732). The ribosome quality control is activated in response to ribosome subunit imbalance, amino acid starvation or downstream the EIF2AK4/GCN2-mediated integrated stress response (ISR) (PubMed:39609413, PubMed:39947182, PubMed:39947183, PubMed:40022732). RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3: monoubiquitinated RPS2/us5 and RPS3/us3 are then recognized by RIOK3 kinase, leading to 18S non-functional rRNA decay and degradation of the 40S ribosomal subunit (PubMed:34348161, PubMed:34469731, PubMed:39609413, PubMed:39947182, PubMed:39947183, PubMed:40022732). The action of RNF10 in iRQC is counteracted by USP10 (PubMed:34469731). {ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:39609413, ECO:0000269|PubMed:39947182, ECO:0000269|PubMed:39947183, ECO:0000269|PubMed:40022732}.