Force generating protein of respiratory cilia (By similarity). Produces force towards the minus ends of microtubules (By similarity). Key component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles (By similarity). {ECO:0000250|UniProtKB:Q22A67, ECO:0000250|UniProtKB:Q8VHE6}. This is the function of DNAH5 (dynein axonemal heavy chain 5, ENSG00000039139).