CTP synthase involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen (PubMed:10899599, PubMed:16179339, PubMed:31873303, PubMed:34583994). Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (PubMed:10899599, PubMed:16179339). {ECO:0000269|PubMed:10899599, ECO:0000269|PubMed:16179339, ECO:0000269|PubMed:31873303, ECO:0000269|PubMed:34583994}. This is the function of ENSG00000047230 (CTPS2, CTP synthase 2).