Membrane-associated scaffold protein that participates in multiple cellular processes, including oxidative stress-induced survival signaling, RNA trafficking and translational regulation, and the modulation of membrane signaling through its interaction with RNA- binding proteins and lipid raft-associated domains (PubMed:19015244). Functions as a regulator of activation of several intracellular kinases, including SRC, FAK, and PI3K, following oxidative stress (PubMed:19015244). Promotes RNA splicing and stability of lipogenic enzymes (PubMed:37595559). Mechanistically, recruits the lipogenic transcription factor SREBP1 at active promoters, thereby bridging the newly transcribed lipogenic genes from RNA polymerase II to the SRSF1 and U1-70K-containing RNA-splicing machinery (PubMed:37595559). Associates with key proteins of the NLRP3 inflammasome pathway and subsequently inhibits NLRP3 inflammasome activation (PubMed:40250624). Sequesters a subset of AGO2-bound mRNAs from miRNA-mediated silencing by binding to poly(G)-rich motifs in their 3'-UTR independently of the AGO2 binding site, likely by preventing recruitment of miRISC effectors (By similarity). {ECO:0000250|UniProtKB:Q6A0A9, ECO:0000269|PubMed:19015244, ECO:0000269|PubMed:37595559, ECO:0000269|PubMed:40250624}. This is the function of FAM120A (family with sequence similarity 120 member A, ENSG00000048828).