Functions as a tRNA-binding adapter to mediate NAT10- dependent tRNA acetylation modifying cytidine to N4-acetylcytidine (ac4C) (PubMed:25653167, PubMed:35196516). . This is the function of ENSG00000066654 (THUMPD1, THUMP domain 1 NAT10 acetyltransferase adaptor ).