The function of PPP2R5B (protein phosphatase 2 regulatory subunit B'beta, Ensembl gene identifier ENSG00000068971) is as follows. As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. .