The function of ENSG00000069275 (NUCKS1, nuclear casein kinase and cyclin dependent kinase substrate 1) is as follows. Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D- loop structures, but with less affinity than RAD51AP1 (PubMed:26323318). .