The function of SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase, Ensembl gene identifier ENSG00000071537) is as follows. Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16186509, PubMed:29997207, PubMed:37943610, PubMed:37943617). Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling. {ECO:0000250|UniProtKB:Q9Z2G6, ECO:0000269|PubMed:16186509, ECO:0000269|PubMed:29997207, ECO:0000269|PubMed:37943610, ECO:0000269|PubMed:37943617}.