The function of CLCN4 (Cl-/H+ antiporter 4, Ensembl gene identifier ENSG00000073464) is as follows. Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (PubMed:18063579, PubMed:23647072, PubMed:25644381, PubMed:27550844, PubMed:28972156). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (PubMed:29845874). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (PubMed:29845874). {ECO:0000269|PubMed:18063579, ECO:0000269|PubMed:23647072, ECO:0000269|PubMed:25644381, ECO:0000269|PubMed:27550844, ECO:0000269|PubMed:28972156, ECO:0000303|PubMed:29845874}.